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Filipe Castro

00Name: Luís Filipe Costa Castro

AggregationIntegrated Member

Type of member: PhD holder researcher

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

CIIMAR R&D Projects

·         Survey of natural substances from marine organisms with potential pharmacological and ecological applications [more info]

·         The modulation of retinoic acid signalling pathways by environmental pollutants in teleosts [more info]

·         Effects of complex mixtures of antagonistic endocrine disrupting chemicals in two fish species with different life histories[more info]

·         The molecular mechanisms of sexual differentiation in gastropods and the role of vertebrate-like steroid hormones[more info]

·         Lipid metabolism disruption in marine fish by xenobiotic ligands of peroxisome proliferator-activated receptors (PPARs)[more info]

·         Peroxisomes, estrogens, and nuclear receptors: cross-talk evaluation in hepatocytes of the trout as a fish model organism - impacts on lipid metabolism [more info]

·         The modulation of retinoid and thyroid signalling pathways by endocrine disrupting chemicals: invertebrate chemicals[more info]

·         The invertebrate repertoire of nuclear receptors: evolutionary and endocrine disruption insights [more info]

CIIMAR Publications (2007-2015)

·         Castro, LFC, Santos, MM. 2014. To bind or not to bind: The taxonomic scope of nuclear receptor mediated endocrine disruption in invertebrate phyla. Environmental Science and Technology 48(10): 5361-5363.http://dx.doi.org/10.1021/es501697b

·         Castro, LFC, Goncalves, O, Mazan, S, Tay, B-H, Venkatesh, B, Wilson, JM. 2014. Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history. Proceedings of the Royal Society B-Biological Sciences 281: 1775. http://dx.doi.org/10.1098/rspb.2013.2669

·         Sárria, MP, Santos, MM, Castro, LF, Vieira, NM, Monteiro, NM. 2013. Estrogenic chemical effects are independent from the degree of sex role reversal in pipefish. Journal of Hazardous Materials 263: 746-753.http://dx.doi.org/10.1016/j.jhazmat.2013.10.043

·         Lopes-Marques, M, Cunha, I, Reis-Henriques, MA, Santos, MM, Castro, LF. 2013. Diversity and history of the long-chain acyl-CoA synthetase (Acsl) gene family in vertebrates. BMC Evolutionary Biology 13: 271. http://dx.doi.org/10.1186/1471-2148-13-271

·         Gesto, M, Castro, LF, Santos, MM. 2013. Differences in retinoid levels and metabolism among gastropod lineages: Imposex-susceptible gastropods lack the ability to store retinoids in the form of retinyl esters. Aquatic Toxicology 142-143: 96-103. http://dx.doi.org/10.1016/j.aquatox.2013.08.001

·         Ferreira, F, Monteiro, NM, Vieira, MN, Reis-Henriques, MA, Castro, LF, Santos, MM. 2013. A real-time PCR assay for differential expression of vitellogenin I and II genes in the liver of the sentinel fish species Lipophrys pholis. Toxicology Mechanisms and Methods 23(8): 591-597. http://dx.doi.org/10.3109/15376516.2013.809620

·         Abidli, S, Castro, LF, Lahbib, Y, Reis-Henriques, MA, Trigui El Menif, N, Santos, MM. 2013. Imposex development in Hexaplex trunculus (Gastropoda: Caenogastropoda) involves changes in the transcription levels of the retinoid X receptor (RXR). Chemosphere 93(6): 1161-1167. http://dx.doi.org/10.1016/j.chemosphere.2013.06.054

·         Castro, LF, Lobo-da-Cunha, A, Rocha, MJ, Urbatzka, R, Rocha, E. 2013. Pex11α in brown trout (Salmo trutta f. fario): Expression dynamics during the reproductive cycle reveals sex-specific seasonal patterns. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology . 164(1): 207-214.http://dx.doi.org/10.1016/j.cbpa.2012.09.003

·         Lima, D, Machado, A, Reis-Henriques, MA, Rocha, E, Santos, MM, Castro, LF. 2013. Cloning and expression analysis of the 17β hydroxysteroid dehydrogenase type 12 (HSD17B12) in the neogastropod Nucella lapillus. The Journal of Steroid Biochemistry and Molecular Biology 134: 8-14. http://dx.doi.org/10.1016/j.jsbmb.2012.10.005

·         Urbatzka, R, Galante-Oliveira, S, Rocha, E, Castro, LFC, Cunha, I. 2013. Normalization strategies for gene expression studies by real-time PCR in a marine fish species, Scophthalmus maximus. Marine Genomics . 10: 17-25.http://dx.doi.org/10.1016/j.margen.2013.02.001

·         Radzisheuskaya, A, Le Bin Chia, G, Dos Santos, RL, Theunissen, TW, Castro, LF, Nichols, J, Silva, JC. 2013. A defined Oct4 level governs cell state transitions of pluripotency entry and differentiation into all embryonic lineages. Nature Cell Biology 15(6):579-90. http://dx.doi.org/10.1038/ncb2742

·         Urbatzka, R, Galante-Oliveira, S, Rocha, E, Castro, LFC, Cunha, I. 2013. Tissue expression of PPAR-alpha isoforms in Scophthalmus maximus and transcriptional response of target genes in the heart after exposure to WY-14643. Fish Physiology and Biochemistry. 39(4): 1043-1055. http://dx.doi.org/10.1007/s10695-012-9761-7

·         Cunha, I, Galante-Oliveira, S, Rocha, E, Planas, M, Urbatzka, R, Castro, LFC. 2013. Dynamics of PPARs, fatty acid metabolism genes and lipid classes in eggs and early larvae of a teleost. Comparative Biochemistry and Physiology Part B – Biochemistry and Molecular Biology 164(4): 247-258. http://dx.doi.org/10.1016/j.cbpb.2013.01.003