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Mónica Marques

03Current position: PhD Student

Reasearch Project: Evolution of Fatty Acid Metabolism in Chordates. 
My PhD aims to study the evolution of fatty acid metabolism in chordates. I am characterizing gene families participating in the regulation FA metabolic processes such as the PPAR Nuclear receptor as well as other nuclear receptors on in several metazoan species. My work often involves extensive blast searches in several databases to identify target genes in several species, phylogenetic analysis and annotation of uncharacterized genes. 

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Degree in Genetics and Biotechnology followed by Masters in Comparative Molecular Genetics awarded by the UTAD University of Trás os Montes and Alto Douro in Vila Real. 


  • Basal gnathostomes provide unique insights into the evolution of vitamin B12 binders; M Lopes-Marques, R Ruivo, I Delgado, JM Wilson, N Aluru, LFC Castro; Genome biology and evolution, evu289, 2014 (doi: 10.1093/gbe/evu289).
  • Diversity and history of the long-chain acyl-CoA synthetase (Acsl) gene family in vertebrates; M Lopes-Marques, I Cunha, MA Reis-Henriques, MM Santos, LFC Castro; BMC evolutionary biology 13 (1), 271, 1, 2013 (doi:10.1186/1471-2148-13-271).
  • The evolution of pepsinogen C genes in vertebrates: duplication, loss and functional diversification; LFC Castro, M Lopes-Marques, O Gonçalves, JM Wilson; PloS one 7 (3), e32852; 2012 (doi:10.1371/journal.pone.0032852).
  • Characterization of the human ornithine transcarbamylase 3′ untranslated regulatory region; M Lopes-Marques, I Pereira-Castro, A Amorim, L Azevedo; DNA and cell biology 31 (4), 427-433, 4, 2012 (doi:10.1089/dna.2011.1391).
  • Human carbamoyl phosphate synthetase I (CPSI): insights on the structural role of the unknown function domains; M Lopes-Marques, G Igrejas, A Amorim, L Azevedo; Biochemical and biophysical research communications 421 (3), 409-412, 2, 2012 (doi:10.1016/j.bbrc.2012.04.033).
  • A novel Acetyl-CoA synthetase short-chain subfamily member 1 (Acss1) gene indicates a dynamic history of paralogue retention and loss in vertebrates.; LF Castro, M Lopes-Marques, JM Wilson, E Rocha, MA Reis-Henriques, MM Santos, I Cunha. Gene, 1, 2012 (doi:10.1016/j.gene.2012.01.013).
  • Consequences of primer binding-sites polymorphisms on genotyping practice. V Laura, E Sofia, LM Mónica, A António, A Luísa; Open Journal of Genetics 2011, 1, 2011 (DOI:10.4236/ojgen.2011.12004).